Ontology highlight
ABSTRACT:
SUBMITTER: Chun HE
PROVIDER: S-EPMC6905433 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Chun Hye-Jung E HE Johann Pascal D PD Milne Katy K Zapatka Marc M Buellesbach Annette A Ishaque Naveed N Iskar Murat M Erkek Serap S Wei Lisa L Tessier-Cloutier Basile B Lever Jake J Titmuss Emma E Topham James T JT Bowlby Reanne R Chuah Eric E Mungall Karen L KL Ma Yussanne Y Mungall Andrew J AJ Moore Richard A RA Taylor Michael D MD Gerhard Daniela S DS Jones Steven J M SJM Korshunov Andrey A Gessler Manfred M Kerl Kornelius K Hasselblatt Martin M Frühwald Michael C MC Perlman Elizabeth J EJ Nelson Brad H BH Pfister Stefan M SM Marra Marco A MA Kool Marcel M
Cell reports 20191107 8
Extra-cranial malignant rhabdoid tumors (MRTs) and cranial atypical teratoid RTs (ATRTs) are heterogeneous pediatric cancers driven primarily by SMARCB1 loss. To understand the genome-wide molecular relationships between MRTs and ATRTs, we analyze multi-omics data from 140 MRTs and 161 ATRTs. We detect similarities between the MYC subgroup of ATRTs (ATRT-MYC) and extra-cranial MRTs, including global DNA hypomethylation and overexpression of HOX genes and genes involved in mesenchymal development ...[more]