Ontology highlight
ABSTRACT:
SUBMITTER: Yip KH
PROVIDER: S-EPMC5095291 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Yip Kwok Ho KH Kolesnikoff Natasha N Hauschild Nicholas N Biggs Lisa L Lopez Angel F AF Galli Stephen J SJ Kumar Sharad S Grimbaldeston Michele A MA
Nature communications 20161027
Cross-linkage of the high-affinity immunoglobulin E (IgE) receptor (FcɛRI) on mast cells by antigen ligation has a critical role in the pathology of IgE-dependent allergic disorders, such as anaphylaxis and asthma. Restraint of intracellular signal transduction pathways that promote release of mast cell-derived pro-inflammatory mediators is necessary to dampen activation and restore homoeostasis. Here we show that the ligase Nedd4-2 and the adaptor Ndfip1 (Nedd4 family interacting protein 1) lim ...[more]