Ontology highlight
ABSTRACT:
SUBMITTER: Brennan LD
PROVIDER: S-EPMC5097161 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Nature communications 20161103
Proper cell function requires preservation of the spatial organization of chromatin modifications. Maintenance of this epigenetic landscape necessitates the transfer of parental nucleosomes to newly replicated DNA, a process that is stringently regulated and intrinsically linked to replication fork dynamics. This creates a formidable setting from which to isolate the central mechanism of transfer. Here we utilized a minimal experimental system to track the fate of a single nucleosome following i ...[more]