Ontology highlight
ABSTRACT:
SUBMITTER: Sun H
PROVIDER: S-EPMC6610759 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Sun Huabing H Zheng Liwei L Yang Kun K Greenberg Marc M MM
Journal of the American Chemical Society 20190625 26
Electron deficient "holes" migrate over long distances through the π-system in free DNA. Hole transfer efficiency (HTE) is strongly dependent on sequence and π-stacking. However, there is no consensus regarding the effects of nucleosome core particle (NCP) environment on hole migration. We quantitatively determined HTE in free DNA and NCPs by independently generating holes at specific positions in DNA. The relative HTE varied widely with respect to position within the NCP and proximity to tyrosi ...[more]