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Positional Dependence of DNA Hole Transfer Efficiency in Nucleosome Core Particles.


ABSTRACT: Electron deficient "holes" migrate over long distances through the ?-system in free DNA. Hole transfer efficiency (HTE) is strongly dependent on sequence and ?-stacking. However, there is no consensus regarding the effects of nucleosome core particle (NCP) environment on hole migration. We quantitatively determined HTE in free DNA and NCPs by independently generating holes at specific positions in DNA. The relative HTE varied widely with respect to position within the NCP and proximity to tyrosine, which suppresses hole transfer. These data indicate that hole transfer in chromatin will be affected by the DNA sequence and its position with respect to histone proteins within NCPs.

SUBMITTER: Sun H 

PROVIDER: S-EPMC6610759 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Positional Dependence of DNA Hole Transfer Efficiency in Nucleosome Core Particles.

Sun Huabing H   Zheng Liwei L   Yang Kun K   Greenberg Marc M MM  

Journal of the American Chemical Society 20190625 26


Electron deficient "holes" migrate over long distances through the π-system in free DNA. Hole transfer efficiency (HTE) is strongly dependent on sequence and π-stacking. However, there is no consensus regarding the effects of nucleosome core particle (NCP) environment on hole migration. We quantitatively determined HTE in free DNA and NCPs by independently generating holes at specific positions in DNA. The relative HTE varied widely with respect to position within the NCP and proximity to tyrosi  ...[more]

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