The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase.
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ABSTRACT:
SUBMITTER: Siala W
PROVIDER: S-EPMC5097165 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase.
Siala Wafi W Kucharíková Soňa S Braem Annabel A Vleugels Jef J Tulkens Paul M PM Mingeot-Leclercq Marie-Paule MP Van Dijck Patrick P Van Bambeke Françoise F
Nature communications 20161103
Biofilms play a major role in Staphylococcus aureus pathogenicity but respond poorly to antibiotics. Here, we show that the antifungal caspofungin improves the activity of fluoroquinolones (moxifloxacin, delafloxacin) against S. aureus biofilms grown in vitro (96-well plates or catheters) and in vivo (murine model of implanted catheters). The degree of synergy among different clinical isolates is inversely proportional to the expression level of ica operon, the products of which synthesize poly- ...[more]
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