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Circulating neuregulin 4 levels are inversely associated with subclinical cardiovascular disease in obese adults.

ABSTRACT: Neuregulin 4 (Nrg4) has been identified as a new secreted adipokine that may protect against development of obesity and metabolic disorders. However, information is not available regarding the association between circulating Nrg4 and subclinical atherosclerosis in humans. We measured serum Nrg4 in 485 obese adult subjects (aged 40 years or older) who had the measurement of carotid intima-media thickness (CIMT) recruited from the community. Individuals with increased CIMT and carotid plaque had lower levels of circulating Nrg4 than controls (p?

SUBMITTER: Jiang J 

PROVIDER: S-EPMC5098181 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Circulating neuregulin 4 levels are inversely associated with subclinical cardiovascular disease in obese adults.

Jiang Jie J   Lin Mingzhu M   Xu Yanfang Y   Shao Jin J   Li Xuejun X   Zhang Huijie H   Yang Shuyu S  

Scientific reports 20161107

Neuregulin 4 (Nrg4) has been identified as a new secreted adipokine that may protect against development of obesity and metabolic disorders. However, information is not available regarding the association between circulating Nrg4 and subclinical atherosclerosis in humans. We measured serum Nrg4 in 485 obese adult subjects (aged 40 years or older) who had the measurement of carotid intima-media thickness (CIMT) recruited from the community. Individuals with increased CIMT and carotid plaque had l  ...[more]

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