Ontology highlight
ABSTRACT:
SUBMITTER: Nakazawa N
PROVIDER: S-EPMC5098635 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Nakazawa Naotaka N Sathe Aneesh R AR Shivashankar G V GV Sheetz Michael P MP
Proceedings of the National Academy of Sciences of the United States of America 20161014 44
Substrate rigidity affects many physiological processes through mechanochemical signals from focal adhesion (FA) complexes that subsequently modulate gene expression. We find that shuttling of the LIM domain (domain discovered in the proteins, Lin11, Isl-1, and Mec-3) protein four-and-a-half LIM domains 2 (FHL2) between FAs and the nucleus depends on matrix mechanics. In particular, on soft surfaces or after the loss of force, FHL2 moves from FAs into the nucleus and concentrates at RNA polymera ...[more]