Ontology highlight
ABSTRACT:
SUBMITTER: Xia Y
PROVIDER: S-EPMC6508970 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Xia Yuntao Y Cho Sangkyun S Vashisth Manasvita M Ivanovska Irena L IL Dingal P C Dave P PCDP Discher Dennis E DE
Methods (San Diego, Calif.) 20181226
Tissues such as brain, muscle, and bone differ greatly not only in their biological functions but also in their mechanical properties. Brain is far softer than muscle while bone is the stiffest tissue. Stiffness of extracellular microenvironments affects fundamental cell biological processes such as polarization and DNA replication, which affect nuclear size, shape, and levels of nuclear proteins such as the lamins that modulate gene expression. Reductionist approaches have helped dissect the ef ...[more]