Ontology highlight
ABSTRACT:
SUBMITTER: Yoon YJ
PROVIDER: S-EPMC5098659 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Yoon Young J YJ Wu Bin B Buxbaum Adina R AR Das Sulagna S Tsai Albert A English Brian P BP Grimm Jonathan B JB Lavis Luke D LD Singer Robert H RH
Proceedings of the National Academy of Sciences of the United States of America 20161017 44
Localization of mRNA is required for protein synthesis to occur within discrete intracellular compartments. Neurons represent an ideal system for studying the precision of mRNA trafficking because of their polarized structure and the need for synapse-specific targeting. To investigate this targeting, we derived a quantitative and analytical approach. Dendritic spines were stimulated by glutamate uncaging at a diffraction-limited spot, and the localization of single β-actin mRNAs was measured in ...[more]