Ontology highlight
ABSTRACT:
SUBMITTER: Cheng RR
PROVIDER: S-EPMC5100047 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Cheng R R RR Nordesjö O O Hayes R L RL Levine H H Flores S C SC Onuchic J N JN Morcos F F
Molecular biology and evolution 20160907 12
Two-component signaling (TCS) is the primary means by which bacteria sense and respond to the environment. TCS involves two partner proteins working in tandem, which interact to perform cellular functions whereas limiting interactions with non-partners (i.e., cross-talk). We construct a Potts model for TCS that can quantitatively predict how mutating amino acid identities affect the interaction between TCS partners and non-partners. The parameters of this model are inferred directly from protein ...[more]