Ontology highlight
ABSTRACT:
SUBMITTER: Ulmschneider B
PROVIDER: S-EPMC5100294 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Ulmschneider Bryne B Grillo-Hill Bree K BK Benitez Marimar M Azimova Dinara R DR Barber Diane L DL Nystul Todd G TG
The Journal of cell biology 20161101 3
Despite extensive knowledge about the transcriptional regulation of stem cell differentiation, less is known about the role of dynamic cytosolic cues. We report that an increase in intracellular pH (pHi) is necessary for the efficient differentiation of Drosophila adult follicle stem cells (FSCs) and mouse embryonic stem cells (mESCs). We show that pHi increases with differentiation from FSCs to prefollicle cells (pFCs) and follicle cells. Loss of the Drosophila Na<sup>+</sup>-H<sup>+</sup> exch ...[more]