Ontology highlight
ABSTRACT:
SUBMITTER: Bergert M
PROVIDER: S-EPMC7875094 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Cell stem cell 20201117 2
Cell differentiation typically occurs with concomitant shape transitions to enable specialized functions. To adopt a different shape, cells need to change the mechanical properties of their surface. However, whether cell surface mechanics control the process of differentiation has been relatively unexplored. Here we show that membrane mechanics gate exit from naive pluripotency of mouse embryonic stem cells. By measuring membrane tension during early differentiation, we find that naive stem cell ...[more]