Ontology highlight
ABSTRACT:
SUBMITTER: Aird KM
PROVIDER: S-EPMC5100296 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Aird Katherine M KM Iwasaki Osamu O Kossenkov Andrew V AV Tanizawa Hideki H Fatkhutdinov Nail N Bitler Benjamin G BG Le Linh L Alicea Gretchen G Yang Ting-Lin TL Johnson F Brad FB Noma Ken-Ichi KI Zhang Rugang R
The Journal of cell biology 20161031 3
Cellular senescence is a stable cell growth arrest that is characterized by the silencing of proliferation-promoting genes through compaction of chromosomes into senescence-associated heterochromatin foci (SAHF). Paradoxically, senescence is also accompanied by increased transcription of certain genes encoding for secreted factors such as cytokines and chemokines, known as the senescence-associated secretory phenotype (SASP). How SASP genes are excluded from SAHF-mediated global gene silencing r ...[more]