The effects of elastic fiber protein insufficiency and treatment on the modulus of arterial smooth muscle cells.
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ABSTRACT:
SUBMITTER: Gabriela Espinosa M
PROVIDER: S-EPMC5101025 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
The effects of elastic fiber protein insufficiency and treatment on the modulus of arterial smooth muscle cells.
Gabriela Espinosa M M Gardner William S WS Bennett Lisa L Sather Bradley A BA Yanagisawa Hiromi H Wagenseil Jessica E JE
Journal of biomechanical engineering 20140201 2
Elastic fibers are critical for the mechanical function of the large arteries. Mechanical effects of elastic fiber protein deficiency have been investigated in whole arteries, but not in isolated smooth muscle cells (SMCs). The elastic moduli of SMCs from elastin (Eln-/-) and fibulin-4 (Fbln4-/-) knockout mice were measured using atomic force microscopy. Compared to control SMCs, the modulus of Eln-/- SMCs is reduced by 40%, but is unchanged in Fbln4-/- SMCs. The Eln-/- SMC modulus is rescued by ...[more]
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