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Static magnetic field controls cell cycle in cultured human glioblastoma cells.

ABSTRACT: Magnetic field has been widely used in clinical diagnostics or for clinical treatment and is an important biomedical technology. Glioblastoma multiforme U87 and U251 are models of a fast growing malignant cancer. We focused on cellular level drafting of these cell lines as a time-dependent effect indicator of static magnetic fields (2000 ± 600 Gauss) by using their fast-growing properties. Cell viability showed a significant decrease (p < 0.01). The results coincided with the occurrence of apoptotic signals or protein expression of cyclin B1 and cyclin dependent kinase 1 in a non-apoptotic manner. Cdk1 was decreased in proportion to ankyrin G and cyclin B1 (Chi-square test, p = 0.0366). Our findings suggest that static magnetic stimulation creates a specific cyto-proliferative pattern, rather than producing randomized growth impairment.

SUBMITTER: Kim SC

PROVIDER: S-EPMC5101323 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Static magnetic field controls cell cycle in cultured human glioblastoma cells.

Kim Seung Chan SC Im Wooseok W Shim Jay Yong JY Kim Seung-Ki SK Kim Beom Jin BJ

Cytotechnology 20160427 6

Magnetic field has been widely used in clinical diagnostics or for clinical treatment and is an important biomedical technology. Glioblastoma multiforme U87 and U251 are models of a fast growing malignant cancer. We focused on cellular level drafting of these cell lines as a time-dependent effect indicator of static magnetic fields (2000 ± 600 Gauss) by using their fast-growing properties. Cell viability showed a significant decrease (p < 0.01). The results coincided with the occurrence of apopt ...[more]

PMID: 27121019

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