Ontology highlight
ABSTRACT:
SUBMITTER: Thapaliya A
PROVIDER: S-EPMC5101480 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Scientific reports 20161109
The fate of secretory and membrane proteins that mislocalize to the cytosol is decided by a collaboration between cochaperone SGTA (small, glutamine-rich, tetratricopeptide repeat protein alpha) and the BAG6 complex, whose operation relies on multiple transient and subtly discriminated interactions with diverse binding partners. These include chaperones, membrane-targeting proteins and ubiquitination enzymes. Recently a direct interaction was discovered between SGTA and the proteasome, mediated ...[more]