Ontology highlight
ABSTRACT:
SUBMITTER: Cherubin P
PROVIDER: S-EPMC5102367 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
PloS one 20161109 11
Cholera toxin (CT) is an AB-type protein toxin that contains a catalytic A1 subunit, an A2 linker, and a cell-binding B homopentamer. The CT holotoxin is released into the extracellular environment, but CTA1 attacks a target within the cytosol of a host cell. We recently reported that grape extract confers substantial resistance to CT. Here, we used a cell culture system to identify twelve individual phenolic compounds from grape extract that inhibit CT. Additional studies determined the mechani ...[more]