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Anti-Metastatic and Anti-Angiogenic Activities of Core-Shell SiO₂@LDH Loaded with Etoposide in Non-Small Cell Lung Cancer.

ABSTRACT: Currently, nanoparticles have gained a great attention in the anti-tumor research area. However, to date, studies on the anti-metastasis action of core-shell SiO₂@LDH (LDH: layered double hydroxide) nanoparticles remain untouched. Two emerging aspects considered are establishing research on the controlling delivery effect of SiO₂@LDH combined with anti-cancer medicine from a new perspective. The fine properties synthetic SiO₂@LDH-VP16 (VP16: etoposide) are practiced to exhibit the nanoparticle's suppression on migration and invasion of non-small cell lung cancer (NSCLC). Both in vitro and in vivo inspection shows that SiO₂@LDH can help VP16 better function as an anti-metastasis agent. On the other hand, anti-angiogenic efficiency, co-localization, as well as western blot are investigated to explain the possible mechanism. A clear mergence of SiO₂@LDH-VP16 and cytomembrane/microtubule may be observed from co-location images. Results offer evidence that SiO₂@LDH-VP16 plays positions on cytomembrane and microtubules. It efficiently inhibits metastasis on NSCLC by reducing vascularization, and eliciting depression of the PI3K-AKT and FAK-Paxillin signaling pathways. SiO₂@LDH-VP16, the overall particle morphology, and function on anti-metastasis and anti-angiogenic may be tuned to give new opportunities for novel strategies for cancer therapy.

SUBMITTER: Zhu Y

PROVIDER: S-EPMC5102674 | biostudies-literature |

REPOSITORIES: biostudies-literature

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