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High-efficient fabrication of core-shell-shell structured SiO2@GdPO4:Tb@SiO2 nanoparticles with improved luminescence.

ABSTRACT: SiO2@GdPO4:Tb@SiO2 nanoparticles with core-shell-shell structure were successfully synthesized by a cheap silane coupling agent grafting method at room temperature. This method not only homogeneously coated rare-earth phosphate nanoparticles on the surface of silica spheres but also saved the use of rare-earth resources. The obtained nanoparticles consisted of SiO2 core with a diameter of approximately 210 nm, GdPO4:Tb intermediate shell with thickness of approximately 7 nm, and SiO2 outer shell with thickness of approximately 20 nm. This unique core-shell-shell structured nanoparticles exhibited strong luminescence properties compared with GdPO4:Tb nanoparticles. The core-shell-shell structured nanoparticles can effectively quench the intrinsic fluorescence of bovine serum albumin through a static quenching mode. The as-synthesized nanoparticles show great potential in biological cell imaging and cancer treatment.

SUBMITTER: Bai H

PROVIDER: S-EPMC7277279 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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High-efficient fabrication of core-shell-shell structured SiO2@GdPO4:Tb@SiO2 nanoparticles with improved luminescence.

Bai He H Yang Yunjiang Y Bao Jinrong J Wu Anping A Qiao Yan Y Guo Xueyuan X Wang Mingyuan M Li Wenxian W Liu Ying Y Zhu Xiaowei X

Royal Society open science 20200527 5

SiO2@GdPO4:Tb@SiO2 nanoparticles with core-shell-shell structure were successfully synthesized by a cheap silane coupling agent grafting method at room temperature. This method not only homogeneously coated rare-earth phosphate nanoparticles on the surface of silica spheres but also saved the use of rare-earth resources. The obtained nanoparticles consisted of SiO2 core with a diameter of approximately 210 nm, GdPO4:Tb intermediate shell wit ...[more]

PMID: 32537211

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Project description:BackgroundUnderstanding the in vivo size-dependent pharmacokinetics and toxicity of nanoparticles is crucial to determine their successful development. Systematic studies on the size-dependent biological effects of nanoparticles not only help to unravel unknown toxicological mechanism but also contribute to the possible biological applications of nanomaterial.MethodsIn this study, the biodistribution and the size-dependent biological effects of Fe3O4@SiO2-NH2 nanoparticles (Fe@Si-NPs) in three diameters (10, 20 and 40 nm) were investigated by ICP-AES, serum biochemistry analysis and NMR-based metabolomic analysis after intravenous administration in a rat model.ResultsOur findings indicated that biodistribution and biological activities of Fe@Si-NPs demonstrated the obvious size-dependent and tissue-specific effects. Spleen and liver are the target tissues of Fe@Si-NPs, and 20 nm of Fe@Si-NPs showed a possible longer blood circulation time. Quantitative biochemical analysis showed that the alterations of lactate dehydrogenase (LDH) and uric acid (UA) were correlated to some extent with the sizes of Fe@Si-NPs. The untargeted metabolomic analyses of tissue metabolomes (kidney, liver, lung, and spleen) indicated that different sizes of Fe@Si-NPs were involved in the different biochemical mechanisms. LDH, formate, uric acid, and GSH related metabolites were suggested as sensitive indicators for the size-dependent toxic effects of Fe@Si-NPs. The findings from serum biochemical analysis and metabolomic analysis corroborate each other. Thus we proposed a toxicity hypothesis that size-dependent NAD depletion may occur in vivo in response to nanoparticle exposure. To our knowledge, this is the first report that links size-dependent biological effects of nanoparticles with in vivo NAD depletion in rats.ConclusionThe integrated metabolomic approach is an effective tool to understand physiological responses to the size-specific properties of nanoparticles. Our results can provide a direction for the future biological applications of Fe@Si-NPs.

Dataset Information

High-efficient fabrication of core-shell-shell structured SiO2@GdPO4:Tb@SiO2 nanoparticles with improved luminescence.

Publications

High-efficient fabrication of core-shell-shell structured SiO<sub>2</sub>@GdPO<sub>4</sub>:Tb@SiO<sub>2</sub> nanoparticles with improved luminescence.

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