Ontology highlight
ABSTRACT:
SUBMITTER: Grieco P
PROVIDER: S-EPMC5102844 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Grieco Paolo P Brancaccio Diego D Novellino Ettore E Hruby Victor J VJ Carotenuto Alfonso A
European journal of medicinal chemistry 20110523 9
The melanocortin receptors are involved in many physiological functions, including pigmentation, sexual function, feeding behavior, and energy homeostasis, making them potential targets to treat obesity, sexual dysfunction, etc. Understanding the basis of the ligand-receptor interactions is crucial for the design of potent and selective ligands for these receptors. The conformational preferences of the cyclic melanocortin ligands MTII (Ac-Nle(4)-c[Asp(5)-His(6)-DPhe(7)-Arg(8)-Trp(9)-Lys(10)]-NH( ...[more]