Ontology highlight
ABSTRACT:
SUBMITTER: Haitina T
PROVIDER: S-EPMC1925065 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Haitina Tatjana T Klovins Janis J Takahashi Akiyoshi A Löwgren Maja M Ringholm Aneta A Enberg Johan J Kawauchi Hiroshi H Larson Earl T ET Fredriksson Robert R Schiöth Helgi B HB
BMC evolutionary biology 20070629
<h4>Background</h4>The melanocortin (MC) receptors have a key role in regulating body weight and pigmentation. They belong to the rhodopsin family of G protein-coupled receptors (GPCRs). The purpose of this study was to identify ancestral MC receptors in agnathan, river lamprey.<h4>Results</h4>We report cloning of two MC receptors from river lamprey. The lamprey receptors, designated MCa and MCb, showed orthology to the MC1 and MC4 receptor subtypes, respectively. The molecular clock analysis su ...[more]