Candidate gene studies of diabetic retinopathy in human.
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ABSTRACT:
SUBMITTER: Priscakova P
PROVIDER: S-EPMC5102952 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Candidate gene studies of diabetic retinopathy in human.
Priščáková Petra P Minárik Gabriel G Repiská Vanda V
Molecular biology reports 20161011 12
Diabetic retinopathy (DR) is a multifactorial disease with complex pathophysiology. It is the main cause of blindness among the people in productive age. The purpose of this literature review is to highlight recent achievements in the genetics of diabetic retinopathy with particular focus on candidate gene studies. We summarized most of the available published data about candidate genes for diabetic retinopathy with the goal to identify main genetic aspects. We conclude that genetic studies repo ...[more]
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Project description:UnlabelledDiabetic retinopathy, is a microvascular complication of diabetes mellitus and is a major cause of adult blindness. Despite advances in diagnosis and treatment the pathogenesis of diabetic retinopathy is not well understood. Results from epidemiological studies of diabetic patients suggest that there are familial predispositions to diabetes and to diabetic retinopathy. Therefore the main purpose of this database is to help both scientists and doctors in studying the candidate genes responsible for causing diabetic retinopathy. For each candidate gene official symbol, chromosome map, number of exons, GT-AG introns, motif, polymorphic variation and 3D structure are given respectively. In addition to molecular class and function of these genes, this database also provides links to download the corresponding nucleotide and amino acid sequences in FASTA format which may be further used for computational approaches. Therefore this database will increase the understanding of the genetics underlying the development or progression of diabetic retinopathy and will have an impact on future diagnostic, prevention and intervention strategies.AvailabilityThe database is freely available at http: diaretinopathydatabase.com.
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