Ontology highlight
ABSTRACT:
SUBMITTER: Liu K
PROVIDER: S-EPMC5103358 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Liu Kun K Zhao Qian Q Liu Pinglei P Cao Jiani J Gong Jiaqi J Wang Chaoqun C Wang Weixu W Li Xiaoyan X Sun Hongyan H Zhang Chao C Li Yufei Y Jiang Minggui M Zhu Shaohua S Sun Qingyuan Q Jiao Jianwei J Hu Baoyang B Zhao Xiaoyang X Li Wei W Chen Quan Q Zhou Qi Q Zhao Tongbiao T
Autophagy 20160811 11
Pluripotent stem cells, including induced pluripotent and embryonic stem cells (ESCs), have less developed mitochondria than somatic cells and, therefore, rely more heavily on glycolysis for energy production. <sup>1-3</sup> However, how mitochondrial homeostasis matches the demands of nuclear reprogramming and regulates pluripotency in ESCs is largely unknown. Here, we identified ATG3-dependent autophagy as an executor for both mitochondrial remodeling during somatic cell reprogramming and mito ...[more]