How Wounding via Lasers Has Potential Photocarcinogenic Preventative Effects via Dermal Remodeling.
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ABSTRACT:
SUBMITTER: Krbanjevic A
PROVIDER: S-EPMC5103639 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
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How Wounding via Lasers Has Potential Photocarcinogenic Preventative Effects via Dermal Remodeling.
Krbanjevic Aleksandar A Travers Jeffrey B JB Spandau Dan F DF
Current dermatology reports 20160707 3
As the incidence of non-melanoma skin cancer (NMSC) is increasing, there is a growing need to identify effective preventive strategies. A recently proposed hypothesis states that NMSC photocarcinogenesis is tightly linked to insufficient insulin growth factor-1 expression by agglomerated senescent fibroblasts in geriatric dermis. This paucity of IGF-1 expression in senile skin allows basal keratinocytes to mitotically propagate their UVB-altered genome and potentially initiate an actinic neoplas ...[more]
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