Ontology highlight
ABSTRACT:
SUBMITTER: Barnett FH
PROVIDER: S-EPMC5105153 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Barnett Faith H FH Rosenfeld Mauricio M Wood Malcolm M Kiosses William B WB Usui Yoshihiko Y Marchetti Valentina V Aguilar Edith E Friedlander Martin M
Scientific reports 20161111
Macrophages, key cells of the innate immune system, are known to support angiogenesis but are not believed to directly form vessel walls. Here we show that macrophages structurally form primitive, NON-ENDOTHELIAL "vessels" or vascular mimicry (VM) channels in both tumor and angiogenesis in vivo models. These channels are functionally connected to the systemic vasculature as they are perfused by intravenously injected dye. Since both models share hypoxic micro-environments, we hypothesized that h ...[more]