Ontology highlight
ABSTRACT:
SUBMITTER: Williamson SC
PROVIDER: S-EPMC5105195 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Williamson Stuart C SC Metcalf Robert L RL Trapani Francesca F Mohan Sumitra S Antonello Jenny J Abbott Benjamin B Leong Hui Sun HS Chester Christopher P E CP Simms Nicole N Polanski Radoslaw R Nonaka Daisuke D Priest Lynsey L Fusi Alberto A Carlsson Fredrika F Carlsson Anders A Hendrix Mary J C MJ Seftor Richard E B RE Seftor Elisabeth A EA Rothwell Dominic G DG Hughes Andrew A Hicks James J Miller Crispin C Kuhn Peter P Brady Ged G Simpson Kathryn L KL Blackhall Fiona H FH Dive Caroline C
Nature communications 20161109
Small cell lung cancer (SCLC) is characterized by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. We show that SCLC patients (37/38) have rare CTC subpopulations co-expressing vascular endothelial-cadherin (VE-cadherin) and cytokeratins consistent with vasculogenic mimicry (VM), a process whereby tumour cells form 'endothelial-like' vessels. Single-cell genomic analysis reveals characteristic SCLC genomic changes in both VE-cadherin-positive and -negative CTCs. Hi ...[more]