Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC5706571 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Li Yanlei Y Sun Baocun B Zhao Xiulan X Wang Xudong X Zhang Danfang D Gu Qiang Q Liu Tieju T
Journal of cellular and molecular medicine 20170802 12
Matrix metalloproteinases (MMPs) have critical functions in tumour vasculogenic mimicry (VM). This study explored the mechanisms underlying MMP-13 and MMP-2 regulation of tumour VM formation in large cell lung cancer (LCLC). In our study, laminin5 (Ln-5) fragments cleaved by MMP-2 promoted tubular structure formation by the LCLC cell lines H460 and H661 in three-dimensional (3D) cultures. Transient up-regulation of MMP-13 or treatment with recombinant MMP-13 protein abrogated tubular structure f ...[more]