Ontology highlight
ABSTRACT:
SUBMITTER: Flint TR
PROVIDER: S-EPMC5106372 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Flint Thomas R TR Janowitz Tobias T Connell Claire M CM Roberts Edward W EW Denton Alice E AE Coll Anthony P AP Jodrell Duncan I DI Fearon Douglas T DT
Cell metabolism 20161101 5
In patients with cancer, the wasting syndrome, cachexia, is associated with caloric deficiency. Here, we describe tumor-induced alterations of the host metabolic response to caloric deficiency that cause intratumoral immune suppression. In pre-cachectic mice with transplanted colorectal cancer or autochthonous pancreatic ductal adenocarcinoma (PDA), we find that IL-6 reduces the hepatic ketogenic potential through suppression of PPARalpha, the transcriptional master regulator of ketogenesis. Whe ...[more]