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Efficacy and Safety of Sofosbuvir/Velpatasvir in Patients With Chronic Hepatitis C Virus Infection Receiving Opioid Substitution Therapy: Analysis of Phase 3 ASTRAL Trials.


ABSTRACT: In this analysis of the ASTRAL trials (non-opioid substitution therapy [OST], n = 984; OST, n = 51) evaluating the once-daily, pan-genotypic regimen of sofosbuvir/velpatasvir for hepatitis C virus infection, OST did not impact completion, adherence, sustained virologic response (SVR12), or safety. SVR12 was 96% (95% confidence interval, 87%, >99%) in those receiving OST.

SUBMITTER: Grebely J 

PROVIDER: S-EPMC5106608 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Efficacy and Safety of Sofosbuvir/Velpatasvir in Patients With Chronic Hepatitis C Virus Infection Receiving Opioid Substitution Therapy: Analysis of Phase 3 ASTRAL Trials.

Grebely Jason J   Dore Gregory J GJ   Zeuzem Stefan S   Aspinall Richard J RJ   Fox Raymond R   Han Lingling L   McNally John J   Osinusi Anu A   Brainard Diana M DM   Subramanian G Mani GM   Natha Macky M   Foster Graham R GR   Mangia Alessandra A   Sulkowski Mark M   Feld Jordan J JJ  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20160823 11


In this analysis of the ASTRAL trials (non-opioid substitution therapy [OST], n = 984; OST, n = 51) evaluating the once-daily, pan-genotypic regimen of sofosbuvir/velpatasvir for hepatitis C virus infection, OST did not impact completion, adherence, sustained virologic response (SVR12), or safety. SVR12 was 96% (95% confidence interval, 87%, >99%) in those receiving OST. ...[more]

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