Ontology highlight
ABSTRACT:
SUBMITTER: Mi Y
PROVIDER: S-EPMC5107143 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Mi Yu Y Wolfram Joy J Mu Chaofeng C Liu Xuewu X Blanco Elvin E Shen Haifa H Ferrari Mauro M
Pharmacological research 20160819 Pt A
Various nanodelivery systems have been designed to release therapeutic agents upon contact with specific enzymes. However, enzyme-triggered release typically takes place in the tissue interstitium, thereby resulting in the extracellular delivery of drugs. Here, we have designed an enzyme-stimulated multistage vector (ESMSV), which enables stimulus-triggered release of drug-encapsulated nanoparticles from a microparticle. Specifically, polymeric nanoparticles with a surface matrix metalloproteina ...[more]