Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC5107171 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Wang Shaoying S Ji Zhouxiang Z Yan Erfu E Haque Farzin F Guo Peixuan P
Virology 20160512
The DNA packaging motor of dsDNA bacterial viruses contains a head-tail connector with a channel for the genome to enter during assembly and to exit during host infection. The DNA packaging motor of bacterial virus phi29 was recently reported to use the "One-way revolving" mechanism for DNA packaging. This raises a question of how dsDNA is ejected during infection if the channel acts as a one-way inward valve. Here we report a three step conformational change of the portal channel that is common ...[more]