Ontology highlight
ABSTRACT:
SUBMITTER: Pradzinska M
PROVIDER: S-EPMC5107209 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Prądzińska Martyna M Behrendt Izabela I Astorga-Wells Juan J Manoilov Aleksandr A Zubarev Roman A RA Kołodziejczyk Aleksandra S AS Rodziewicz-Motowidło Sylwia S Czaplewska Paulina P
Amino acids 20160829 12
Human cystatin C (hCC) is a small cysteine protease inhibitor whose oligomerization by propagated domain swapping is linked to certain neurological disorders. One of the ways to prevent hCC dimerization and fibrillogenesis is to enable its interaction with a proper antibody. Herein, the sites of interaction of hCC with dimer-preventing mouse monoclonal anti-hCC antibodies Cyst28 are studied and compared with the binding sites found for mAb Cyst10 that has almost no effect on hCC dimerization. In ...[more]