Ontology highlight
ABSTRACT:
SUBMITTER: Cairns J
PROVIDER: S-EPMC5107984 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Cairns Junmei J Ung Choong Yong CY da Rocha Edroaldo Lummertz EL Zhang Cheng C Correia Cristina C Weinshilboum Richard R Wang Liewei L Li Hu H
Scientific reports 20161114
To better address the problem of drug resistance during cancer chemotherapy and explore the possibility of manipulating drug response phenotypes, we developed a network-based phenotype mapping approach (P-Map) to identify gene candidates that upon perturbed can alter sensitivity to drugs. We used basal transcriptomics data from a panel of human lymphoblastoid cell lines (LCL) to infer drug response networks (DRNs) that are responsible for conferring response phenotypes for anthracycline and taxa ...[more]