Ontology highlight
ABSTRACT:
SUBMITTER: Huber N
PROVIDER: S-EPMC5107993 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Huber Nina N Bieniossek Christoph C Wagner Konstanze Marion KM Elsässer Hans-Peter HP Suter Ueli U Berger Imre I Niemann Axel A
Scientific reports 20161114
Mutations in the ganglioside-induced differentiation associated protein 1 (GDAP1) cause severe peripheral motor and sensory neuropathies called Charcot-Marie-Tooth disease. GDAP1 expression induces fission of mitochondria and peroxisomes by a currently elusive mechanism, while disease causing mutations in GDAP1 impede the protein's role in mitochondrial dynamics. In silico analysis reveals sequence similarities of GDAP1 to glutathione S-transferases (GSTs). However, a proof of GST activity and i ...[more]