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Nebraska Red: a phosphinate-based near-infrared fluorophore scaffold for chemical biology applications.


ABSTRACT: A series of novel phosphinate-based dyes displaying near-infrared fluorescence (NIR) are reported. These dyes exhibit remarkable photostability and brightness. The phosphinate functionality is leveraged as an additional reactive handle in order to tune cell permeability as well as provide a proof-of-principle for a self-reporting small molecule delivery vehicle.

SUBMITTER: Zhou X 

PROVIDER: S-EPMC5108567 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Nebraska Red: a phosphinate-based near-infrared fluorophore scaffold for chemical biology applications.

Zhou Xinqi X   Lai Rui R   Beck Jon R JR   Li Hui H   Stains Cliff I CI  

Chemical communications (Cambridge, England) 20161001 83


A series of novel phosphinate-based dyes displaying near-infrared fluorescence (NIR) are reported. These dyes exhibit remarkable photostability and brightness. The phosphinate functionality is leveraged as an additional reactive handle in order to tune cell permeability as well as provide a proof-of-principle for a self-reporting small molecule delivery vehicle. ...[more]

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