Ontology highlight
ABSTRACT:
SUBMITTER: Hong M
PROVIDER: S-EPMC5110018 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Hong MeeAe M Schwerk Johannes J Lim Chrissie C Kell Alison A Jarret Abigail A Pangallo Joseph J Loo Yueh-Ming YM Liu Shuanghu S Hagedorn Curt H CH Gale Michael M Savan Ram R
The Journal of experimental medicine 20161031 12
Interferon (IFN) lambdas are critical antiviral effectors in hepatic and mucosal infections. Although IFNλ1, IFNλ2, and IFNλ3 act antiviral, genetic association studies have shown that expression of the recently discovered IFNL4 is detrimental to hepatitis C virus (HCV) infection through a yet unknown mechanism. Intriguingly, human IFNL4 harbors a genetic variant that introduces a premature stop codon. We performed a molecular and biochemical characterization of IFNλ4 to determine its role and r ...[more]