Ontology highlight
ABSTRACT:
SUBMITTER: Mann SI
PROVIDER: S-EPMC5110120 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Mann Samuel I SI Heinisch Tillmann T Weitz Andrew C AC Hendrich Michael P MP Ward Thomas R TR Borovik A S AS
Journal of the American Chemical Society 20160714 29
Cupredoxins are electron-transfer proteins that have active sites containing a mononuclear Cu center with an unusual trigonal monopyramidal structure (Type 1 Cu). A single Cu-Scys bond is present within the trigonal plane that is responsible for its unique physical properties. We demonstrate that a cysteine-containing variant of streptavidin (Sav) can serve as a protein host to model the structure and properties of Type 1 Cu sites. A series of artificial Cu proteins are described that rely on Sa ...[more]