Ontology highlight
ABSTRACT:
SUBMITTER: Hamaoka BY
PROVIDER: S-EPMC511037 | biostudies-literature | 2004 Aug
REPOSITORIES: biostudies-literature
Hamaoka Brent Y BY Dann Charles E CE Geisbrecht Brian V BV Leahy Daniel J DJ
Proceedings of the National Academy of Sciences of the United States of America 20040802 32
HER-1 is a secreted protein that promotes male development in the nematode Caenorhabditis elegans. HER-1 inhibits the function of TRA-2A, a multipass integral membrane protein thought to serve as its receptor. We report here the 1.5-A crystal structure of HER-1. The structure was solved by the multiwavelength anomalous diffraction method by using selenomethionyl-substituted HER-1 produced in Chinese hamster ovary cells. The HER-1 structure consists of two all-helical domains and is not closely h ...[more]