Ontology highlight
ABSTRACT:
SUBMITTER: Hastie EL
PROVIDER: S-EPMC5110387 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Hastie Eric L EL Sherwood David R DR
European journal of cell biology 20160624 11
Invadopodia are F-actin-rich membrane protrusions that breach basement membrane barriers during cell invasion. Since their discovery more than 30 years ago, invadopodia have been extensively investigated in cancer cells in vitro, where great advances in understanding their composition, formation, cytoskeletal regulation, and control of the matrix metalloproteinase MT1-MMP trafficking have been made. In contrast, few studies examining invadopodia have been conducted in vivo, leaving their physiol ...[more]