Ontology highlight
ABSTRACT:
SUBMITTER: Zanoni I
PROVIDER: S-EPMC5111085 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Zanoni Ivan I Tan Yunhao Y Di Gioia Marco M Broggi Achille A Ruan Jianbin J Shi Jianjin J Donado Carlos A CA Shao Feng F Wu Hao H Springstead James R JR Kagan Jonathan C JC
Science (New York, N.Y.) 20160421 6290
Dendritic cells (DCs) use pattern recognition receptors to detect microorganisms and activate protective immunity. These cells and receptors are thought to operate in an all-or-nothing manner, existing in an immunologically active or inactive state. Here, we report that encounters with microbial products and self-encoded oxidized phospholipids (oxPAPC) induce an enhanced DC activation state, which we call "hyperactive." Hyperactive DCs induce potent adaptive immune responses and are elicited by ...[more]