The retrotrapezoid nucleus and breathing.
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ABSTRACT:
SUBMITTER: Guyenet PG
PROVIDER: S-EPMC5111164 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
The retrotrapezoid nucleus and breathing.
Guyenet Patrice G PG Stornetta Ruth L RL Abbott Stephen B G SB Depuy Seth D SD Kanbar Roy R
Advances in experimental medicine and biology 20120101
The retrotrapezoid nucleus (RTN) is located in the rostral medulla oblongata close to the ventral surface and consists of a bilateral cluster of glutamatergic neurons that are non-aminergic and express homeodomain transcription factor Phox2b throughout life. These neurons respond vigorously to increases in local pCO(2) via cell-autonomous and paracrine (glial) mechanisms and receive additional chemosensory information from the carotid bodies. RTN neurons exclusively innervate the regions of the ...[more]
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