PHYSIOLOGY. Regulation of breathing by CO? requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons.
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SUBMITTER: Kumar NN
PROVIDER: S-EPMC5171229 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
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PHYSIOLOGY. Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons.
Kumar Natasha N NN Velic Ana A Soliz Jorge J Shi Yingtang Y Li Keyong K Wang Sheng S Weaver Janelle L JL Sen Josh J Abbott Stephen B G SB Lazarenko Roman M RM Ludwig Marie-Gabrielle MG Perez-Reyes Edward E Mohebbi Nilufar N Bettoni Carla C Gassmann Max M Suply Thomas T Seuwen Klaus K Guyenet Patrice G PG Wagner Carsten A CA Bayliss Douglas A DA
Science (New York, N.Y.) 20150611 6240
Blood gas and tissue pH regulation depend on the ability of the brain to sense CO2 and/or H(+) and alter breathing appropriately, a homeostatic process called central respiratory chemosensitivity. We show that selective expression of the proton-activated receptor GPR4 in chemosensory neurons of the mouse retrotrapezoid nucleus (RTN) is required for CO2-stimulated breathing. Genetic deletion of GPR4 disrupted acidosis-dependent activation of RTN neurons, increased apnea frequency, and blunted ven ...[more]
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