Ontology highlight
ABSTRACT:
SUBMITTER: Blinka S
PROVIDER: S-EPMC5111363 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Blinka Steven S Reimer Michael H MH Pulakanti Kirthi K Rao Sridhar S
Cell reports 20160901 1
Super-enhancers are tissue-specific cis-regulatory elements that drive expression of genes associated with cell identity and malignancy. A cardinal feature of super-enhancers is that they are transcribed to produce enhancer-derived RNAs (eRNAs). It remains unclear whether super-enhancers robustly activate genes in situ and whether their functions are attributable to eRNAs or the DNA element. CRISPR/Cas9 was used to systematically delete three discrete super-enhancers at the Nanog locus in embryo ...[more]