Ontology highlight
ABSTRACT:
SUBMITTER: Wang AH
PROVIDER: S-EPMC5659763 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Wang A Hongjun AH Juan Aster H AH Ko Kyung Dae KD Tsai Pei-Fang PF Zare Hossein H Dell'Orso Stefania S Sartorelli Vittorio V
Molecular cell 20171012 2
Spt6 coordinates nucleosome dis- and re-assembly, transcriptional elongation, and mRNA processing. Here, we report that depleting Spt6 in embryonic stem cells (ESCs) reduced expression of pluripotency factors, increased expression of cell-lineage-affiliated developmental regulators, and induced cell morphological and biochemical changes indicative of ESC differentiation. Selective downregulation of pluripotency factors upon Spt6 depletion may be mechanistically explained by its enrichment at ESC ...[more]