Higher hydrocortisone dose increases bilirubin in hypopituitary patients- results from an RCT.

ABSTRACT:

Background

Bilirubin has anti-oxidative and anti-inflammatory properties, which may explain its proposed protective effects on the development of cardiometabolic disorders. Glucocorticoids affect heme oxygenase regulation in vitro, which plays a key role in bilirubin production. Effects of variations in glucocorticoid exposure on circulating bilirubin levels in humans are unknown. Here we tested whether a higher hydrocortisone replacement dose affects circulating bilirubin in hypopituitary patients.

Materials and methods

A randomized double-blind cross-over study (ClinicalTrials.gov, number NCT01546992) was performed in 47 patients with secondary adrenal failure [10-week exposure to a higher hydrocortisone dose (0·4-0·6 mg/kg body weight) vs. 10 weeks of a lower hydrocortiso

SUBMITTER: Werumeus Buning J 

PROVIDER: S-EPMC5111743 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature