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Scalable procedure for the fragmentation of hydroperoxides mediated by copper and iron tetrafluoroborate salts.

ABSTRACT: An improved protocol for the formal elimination of propene from organic substrates is reported. This process entails the ozonolytic conversion of an alkene to a methoxy hydroperoxide which undergoes fragmentation mediated by copper and iron. The use of soluble Cu(BF4)2 and Fe(BF4)2 results in reproducible results up to a 100 gram scale.

SUBMITTER: Huang D

PROVIDER: S-EPMC5111968 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Scalable procedure for the fragmentation of hydroperoxides mediated by copper and iron tetrafluoroborate salts.

Huang David D Schuppe Alexander W AW Liang Michael Z MZ Newhouse Timothy R TR

Organic & biomolecular chemistry 20160607 26

An improved protocol for the formal elimination of propene from organic substrates is reported. This process entails the ozonolytic conversion of an alkene to a methoxy hydroperoxide which undergoes fragmentation mediated by copper and iron. The use of soluble Cu(BF4)2 and Fe(BF4)2 results in reproducible results up to a 100 gram scale. ...[more]

PMID: 27273761

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