Ontology highlight
ABSTRACT:
SUBMITTER: Crooke ST
PROVIDER: S-EPMC5112040 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Crooke Stanley T ST Baker Brenda F BF Kwoh T Jesse TJ Cheng Wei W Schulz Dan J DJ Xia Shuting S Salgado Nelson N Bui Huynh-Hoa HH Hart Christopher E CE Burel Sebastien A SA Younis Husam S HS Geary Richard S RS Henry Scott P SP Bhanot Sanjay S
Molecular therapy : the journal of the American Society of Gene Therapy 20160630 10
The common chemical and biological properties of antisense oligonucleotides provide the opportunity to identify and characterize chemical class effects across species. The chemical class that has proven to be the most versatile and best characterized is the 2'-O-methoxyethyl chimeric antisense oligonucleotides. In this report we present an integrated safety assessment of data obtained from controlled dose-ranging studies in nonhuman primates (macaques) and healthy human volunteers for 12 unique ...[more]