Ontology highlight
ABSTRACT:
SUBMITTER: Le MX
PROVIDER: S-EPMC5112545 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Scientific reports 20161117
Class switch recombination (CSR) in B cells requires the timely repair of DNA double-stranded breaks (DSBs) that result from lesions produced by activation-induced cytidine deaminase (AID). Through a genome-wide RNAi screen, we identified Kin17 as a gene potentially involved in the maintenance of CSR in murine B cells. In this study, we confirm a critical role for Kin17 in CSR independent of AID activity. Furthermore, we make evident that DSBs generated by AID or ionizing radiation require Kin17 ...[more]