Ontology highlight
ABSTRACT:
SUBMITTER: Gerakis Y
PROVIDER: S-EPMC5112606 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Gerakis Yannis Y Dunys Julie J Bauer Charlotte C Checler Fréderic F
Scientific reports 20161117
The aspartyl protease β-site APP cleaving enzyme, BACE1, is the rate-limiting enzyme involved in the production of amyloid-β peptide, which accumulates in both sporadic and familial cases of Alzheimer's disease and is at the center of gravity of the amyloid cascade hypothesis. In this context, unravelling the molecular mechanisms controlling BACE1 expression and activity in both physiological and pathological conditions remains of major importance. We previously demonstrated that Aβ controlled B ...[more]