Ontology highlight
ABSTRACT:
SUBMITTER: Ristori T
PROVIDER: S-EPMC5113129 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Ristori Tommaso T Vigliotti Andrea A Baaijens Frank P T FPT Loerakker Sandra S Deshpande Vikram S VS
Biophysical journal 20161101 10
Cells respond to both mechanical and topographical stimuli by reorienting and reorganizing their cytoskeleton. Under certain conditions, such as for cells on cyclically stretched grooved substrates, the effects of these stimuli can be antagonistic. The biophysical processes that lead to the cellular reorientation resulting from such a competition are not clear yet. In this study, we hypothesized that mechanical cues and the diffusion of the intracellular signal produced by focal adhesions are de ...[more]